Changes in gene expression during G-CSF–induced emergency granulopoiesis in humans
CC Pedersen, R Borup, A Fischer-Nielsen… - The Journal of …, 2016 - journals.aai.org
Emergency granulopoiesis refers to the increased production of neutrophils in bone marrow
and their release into circulation induced by severe infection. Several studies point to a
critical role for G-CSF as the main mediator of emergency granulopoiesis. However, the
consequences of G-CSF stimulation on the transcriptome of neutrophils and their precursors
have not yet been investigated in humans. In this work, we examine the changes in mRNA
expression induced by administration of G-CSF in vivo, as a model of emergency …
and their release into circulation induced by severe infection. Several studies point to a
critical role for G-CSF as the main mediator of emergency granulopoiesis. However, the
consequences of G-CSF stimulation on the transcriptome of neutrophils and their precursors
have not yet been investigated in humans. In this work, we examine the changes in mRNA
expression induced by administration of G-CSF in vivo, as a model of emergency …
Changes in Gene Expression during G-CSF-Induced Emergency Granulopoiesis in Humans
CC Pedersen, R Borup, A Fischer-Nielsen… - 2015 - ashpublications.org
Emergency granulopoiesis refers to the increased production of neutrophils in bone marrow
and their release into circulation induced by severe infection. Several studies point to a
critical role for granulocyte colony-stimulating factor (G-CSF) as the main mediator of
emergency granulopoiesis. However, the consequences of G-CSF stimulation on the
transcriptome of neutrophils and their precursors have not yet been elucidated in humans.
Here, we investigate the changes in mRNA and miRNA expression in successive stages of …
and their release into circulation induced by severe infection. Several studies point to a
critical role for granulocyte colony-stimulating factor (G-CSF) as the main mediator of
emergency granulopoiesis. However, the consequences of G-CSF stimulation on the
transcriptome of neutrophils and their precursors have not yet been elucidated in humans.
Here, we investigate the changes in mRNA and miRNA expression in successive stages of …
